For perspective, I have over 17,000 posts with nearly 60 custom fields per post as well as querying Amazon for ads specific to that post. With W3 Total Cache installed and using APC caching, object caching, browser caching and Varnish with reverse proxy my front-end post load times are around 2.38 seconds and that's with over 148 queries per post. Plugin overhead is around .5 of a second. This is on a PAAS with 1Gb RAM and 16PHP's processes available to it. I'm just wondering if you have explored appropriate caching options?
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